Journal
BLOOD
Volume 119, Issue 23, Pages E151-E160Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2012-01-407528
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Funding
- Academy of Finland (Center of Excellence in Molecular Systems Immunology and Physiology Research) [250114, 207490 SYSBIO, 116639, 115939, 140019]
- European Commission Seventh Framework grants [EC-FP7-SYBILLA-201106, EC-FP7-NANOMMUNE-214281, EC-FP7-DIABIMMUNE-202063]
- JDRF
- Sigrid Juselius Foundation
- Turku University Hospital grant
- Turku University Foundation
- BBSRC [BB/I004114/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I004114/1] Funding Source: researchfish
- Academy of Finland (AKA) [140019, 140019, 116639, 115939] Funding Source: Academy of Finland (AKA)
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Th17 cells play an essential role in the pathogenesis of autoimmune and inflammatory diseases. Most of our current understanding on Th17 cell differentiation relies on studies carried out in mice, whereas the molecular mechanisms controlling human Th17 cell differentiation are less well defined. In this study, we identified gene expression changes characterizing early stages of human Th17 cell differentiation through genome-wide gene expression profiling. CD4(+) cells isolated from umbilical cord blood were used to determine detailed kinetics of gene expression after initiation of Th17 differentiation with IL1 beta, IL6, and TGF beta. The differential expression of selected candidate genes was further validated at protein level and analyzed for specificity in initiation of Th17 compared with initiation of other Th subsets, namely Th1, Th2, and iTreg. This first genome-wide profiling of transcriptomics during the induction of human Th17 differentiation provides a starting point for defining gene regulatory networks and identifying new candidates regulating Th17 differentiation in humans. (Blood. 2012;119(23):e151-e160)
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