Journal
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Volume 9, Issue 8, Pages NC8-NC11Publisher
PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
DOI: 10.7860/JCDR/2015/12888.6402
Keywords
Choroid; Choroidal volume; OCT
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Background: During pregnancy the maternal choroid is exposed to the multiple haemodynamic and hormonal alterations inherent to this physiological condition. These changes may influence choroidal anatomy. In this study a quantitative assessment of overall choroidal structure is performed, by constructing a 3-dimensional topographic map of this vascular bed. Purpose: To compare the thickness and volume of the maternal choroidal in the third trimester of pregnancy with that of an age-matched control group of women. Materials and Methods: Twenty-four eyes of 12 pregnant women in the last trimester and 12 age-matched healthy controls (24 eyes) were included. Optical coherence tomography in enhanced depth imaging mode was used to construct maps of the choroid of the macular area. Choroidal thickness and volume were automatically calculated for the 9 subfields defined by the Early Treatment Diabetic Retinopathy Study (ETDRS). A comparative analysis between the two groups was performed using the two-way ANOVA test. Results: The average thickness of the choroid for the entire ETDRS area of the pregnant group was 295.15 +/- 42.40 mu m and 271.56 +/- 37.65 mu m in the control group (p=0.051). The average choroidal volume was 8.05 +/- 1.12mm(3) and 7.46 +/- 1.03mm(3), respectively (p=0.067). Although the choroid of the pregnant group had larger thickness and volume in all subfields compared to the control group, this difference was statistically significant only in three regions-the central subfield, minimum foveal thickness and inferior inner macula (p<0.05). Conclusion: Our study suggests that in the third trimester of pregnancy the choroid may be subjected to physiological changes in structure. Whether these changes are a result of hormonal and/or haemodynamic adaptations of pregnancy remains to be studied.
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