Journal
BLOOD
Volume 117, Issue 13, Pages 3692-3694Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-11-319053
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Funding
- Fondation pour la Recherche Medicale
- Program Hospitalier de recherche Clinique [PHRC 20 002, PHRC2009 RENOVA-TV]
- Fondation de France
- Leducq Foundation
- Agence Nationale pour la Recherche [ANR-07-MRAR-021]
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Agence Francaise de Securite Sanitaire des Produits de Sante
- regional government of Aquitaine
- regional government of Bourgogne
- regional government of Languedoc-Roussillon
- Ministry of Research-Inserm
- Eisai
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Three single nucleotide polymorphisms (SNPs) were recently found to be associated with activated partial thromboplastin time (aPTT). Because shortened aPTT levels have been observed in patients experiencing venous thrombosis (VT), we investigated the effects of these 3 aPTT-associated SNPs, rs2731672, rs9898, and rs710446, on the risk of VT in a sample of 1110 healthy patients and 1542 patients with VT. Among the 3 tested SNPs, only rs710446 was associated with VT risk; the rs710446-C allele was associated with an increased risk of VT (odds ratio 1.196, 95% confidence interval 1.071-1.336, P = .0012). This association also was observed in an independent sample of 590 controls and 596 patients (odds ratio 1.171, 95% confidence interval 0.889-1.541, P = .059). We also confirmed that the rs710446-C allele was associated with decreased aPTT levels, making this nonsynonymous Ile581Thr variant a new genetic risk factor for VT. (Blood. 2011; 117(13): 3692-3694)
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