Journal
BLOOD
Volume 118, Issue 13, Pages E74-E81Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-04-348748
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Funding
- Wellcome Trust of Great Britain, as part of Wellcome Trust-Mahidol University
- Agency for Science Technology and Research (A*STAR
- Singapore)
- Wellcome Trust (United Kingdom)
- ITM
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Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. The assay is based on mixing enriched cord blood reticulocytes with matured, trypsin-treated P vivax schizonts concentrated from clinical isolates. The reliability of this assay was demonstrated using a large panel of P vivax isolates freshly collected from patients in Thailand. (Blood. 2011;118(13):e74-e81)
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