Journal
BLOOD
Volume 117, Issue 20, Pages 5449-5452Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-11-318956
Keywords
-
Categories
Funding
- National Health and Medical Research Council (NHMRC) of Australia
- Sylvia and Charles Viertel Charitable Foundation
- Howard Hughes Medical Institute
- Pfizer
- Leukemia Foundation of Australia
- NHMRC
Ask authors/readers for more resources
Natural killer (NK) cells are generated in the bone marrow (BM) from lymphoid progenitors. Although several different maturation states of committed NK cells have been described, the initial stages of NK-cell differentiation from the common lymphoid progenitor are not well under-stood. Here we describe the identification of the earliest committed NK-cell precursors in the BM. These precursors, termed pre-pro NK cells, lack the expression of most canonical NK cell-specific surface markers but express the transcription factor inhibitor of DNA binding 2 and highlevels of the IL-7 receptor. In vitro differentiation studies demonstrate that pre-pro NK cells are committed to NK-cell lineage and appear to be upstream of the previously identified NK-cell progenitor population. (Blood. 2011;117(20):5449-5452)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available