Journal
BLOOD
Volume 118, Issue 3, Pages 609-617Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-11-319699
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Funding
- Agence Nationale de la Recherche (BAD-LAMP layers)
- La Ligue Nationale Contre le Cancer
- Agence Nationale de Recherche sur le Sida
- Ministere de l'enseignement superieur et de la recherche (MESR)
- Region Provence-Alpes-Cote d'Azur (PACA)
- Ligue Nationale Contre le Cancer (LNCC)
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The brain and dendritic cell (BAD)associated lysosome-associated membrane protein (LAMP)-like molecule (BAD-LAMP, c20orf103, UNC-46) is a newly identified member of the family of LAMPs. BAD-LAMP expression in the mouse is confined to neurons. We demonstrate here that in humans, BAD-LAMP can specifically be found in the type I IFN-producing plasmacytoid dendritic cells (pDCs). Human BAD-LAMP is localized in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of freshly isolated CD123(+) pDCs and is rapidly lost upon activation by unmethylated cytosine-phosphate-guanine (CpG) oligonucleotides. The restricted pattern of BAD-LAMP expression allows for the rapid identification of normal and leukemic human pDCs in tissues and blood. (Blood. 2011;118(3):609-617)
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