Journal
JOURNAL OF CLINICAL ANESTHESIA
Volume 27, Issue 2, Pages 175-180Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinane.2014.09.011
Keywords
Renal blood flow; Sepsis; Septic AKI; Ischemia reperfusion injury; RIFLE criteria; Renal autoregulation
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Acute kidney injury is a frequent complication in the intensive care unit that is associated with increased mortality and morbidity. Traditional models consider reductions of global renal blood flow as the cause of acute kidney injury. However, a complex interplay between ischemia-reperfusion injury and inflammation may lead to intrarenal hypoperfusion and acute kidney injury. The role of changes of global renal blood flow as a cause for acute kidney injury remains controversial, especially in sepsis-induced acute kidney injury. (C) 2014 Elsevier Inc. All rights reserved.
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