Journal
BLOOD
Volume 118, Issue 3, Pages 675-678Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-03-344069
Keywords
-
Categories
Funding
- Intergroupe Francophone du Myelome
- French National Research Agency [R08079NS]
- French Institute National du Cancer [R09076NN]
- National Institutes of Health [PO1 CA155258-01]
Ask authors/readers for more resources
Multiple myeloma (MM) develops from a premalignant plasma cell proliferative disorder, and with time can progress to a more aggressive disease in extramedullary locations. The gradually clinical evolution is supported by clonal expansion of cells that acquire genetic lesions over years. This model of cancer evolution based on ongoing genomic instability mechanism may apply to development of most MM cases. However, in a small fraction of newly diagnosed MM who relapse quickly and finally die within 2 years, the gradual model appears to be untenable. Analysis of high resolution copy number profiles obtained using single nucleotide polymorphism array data from 764 newly diagnosed MM identified large numbers of genomic rearrangements with the hallmarks of chromothripsis in 1.3% of samples. Moreover, this catastrophic event confers a poor outcome. Because chromothripsis appears to occur in a single crisis, our results suggest that high-risk MM patients use this novel way of cancer evolution. (Blood. 2011;118(3):675-678)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available