Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 48, Issue 3, Pages 563-580Publisher
IOS PRESS
DOI: 10.3233/JAD-150395
Keywords
Alzheimer's disease; amyotrophic lateral sclerosis; epilepsy; Huntington's disease; miRNAs; neurodegenerative disorders; Parkinson's disease
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Funding
- University of Hyderabad
- Krishna Institute of Medical Sciences (KIMS), Hyderabad, India
- Intramural Research Program of the National Institute on Aging (NHG, IAT), Baltimore, MD, USA
- NATIONAL INSTITUTE ON AGING [ZIAAG000311] Funding Source: NIH RePORTER
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MicroRNAs (miRNAs) are endogenous, similar to 22 nucleotide, non-coding RNA molecules that function as posttranscriptional regulators of gene expression. miRNA dysregulation has been observed in cancer and in neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and the neurological disorder, epilepsy. Neuronal degradation and death are important hallmarks of neurodegenerative disorders. Additionally, abnormalities in metabolism, synapsis and axonal transport have been associated with Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. A number of recently published studies have demonstrated the importance of miRNAs in the nervous system and have contributed to the growing body of evidence on miRNA dysregulation in neurological disorders. Knowledge of the expressions and activities of such miRNAs may aid in the development of novel therapeutics. In this review, we discuss the significance of miRNA dysregulation in the development of neurodegenerative disorders and the use of miRNAs as targets for therapeutic intervention.
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