Journal
BLOOD
Volume 118, Issue 25, Pages 6506-6514Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-08-376061
Keywords
-
Categories
Funding
- Italian Ministry of University and Scientific Research
- Fondazione CARIVERONA
- Microambiente e progressione neoplastica: il network di regolazione indotto da cellule stromali. Biologia e applicazioni terapeutiche
- Utilizzo delle capacita rigenerative ed immunoregolatorie delle cellule staminali mesenchimali per il trattamento di patologie ossee, neurologiche e cardiologiche
Ask authors/readers for more resources
Notch signaling pathway regulates many different events of embryonic and adult development; among them, Notch plays an essential role in the onset of hematopoietic stem cells and influences multiple maturation steps of developing lymphoid and myeloid cells. Deregulation of Notch signaling determines several human disorders, including cancer. In the last decade it became evident that Notch signaling plays pivotal roles in the onset and development of T-and B-cell acute lym-phoblastic leukemia by regulating the intracellular molecular pathways involved in leukemia cell survival and proliferation. On the other hand, bone marrow stromal cells are equally necessary for leukemia cell survival by preventing blast cell apoptosis and favoring their reciprocal interactions and cross-talk with bone marrow microenvironment. Quite surprisingly, the link between Notch signaling pathway and bone marrow stromal cells in acute lymphoblastic leukemia has been pointed out only recently. In fact, bone marrow stromal cells express Notch receptors and ligands, through which they can interact with and influence normal and leukemia T-and B-cell survival. Here, the data concerning the development of T-and B-cell acute lymphoblastic leukemia has been critically reviewed in light of the most recent findings on Notch signaling in stromal microenvironment. (Blood. 2011; 118(25): 6506-6514)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available