Journal
BLOOD
Volume 117, Issue 19, Pages 5088-5091Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-01-329516
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Funding
- Netherlands Organisation for Scientific Research [917-76-345, 916-36-601]
- National Institutes of Health [R37 DK51077]
- MRC [G0800784] Funding Source: UKRI
- Medical Research Council [G0800784, G0800784B] Funding Source: researchfish
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CD41 expression is associated with the earliest stages of mouse hematopoiesis. It is notably expressed on some cells of the intra-aortic hematopoietic clusters, an area where the first adult-repopulating hematopoietic stem cells (HSCs) are generated. Although it is generally accepted that CD41 expression marks the onset of primitive/definitive hematopoiesis, there are few published data concerning its expression on HSCs. It is as yet uncertain whether HSCs express CD41 throughout development, and if so, to what level. We performed a complete in vivo transplantation analysis with yolk sac, aorta, placenta, and fetal liver cells, sorted based on CD41 expression level. Our data show that the earliest emerging HSCs in the aorta express CD41 in a time-dependent manner. In contrast, placenta and liver HSCs are CD41(-). Thus, differential and temporal expression of CD41 by HSCs in the distinct hematopoietic territories suggests a developmental/dynamic regulation of this marker throughout development. (Blood. 2011; 117(19): 5088-5091)
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