Journal
BLOOD
Volume 116, Issue 5, Pages 767-771Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-11-251926
Keywords
-
Categories
Funding
- National Institutes of Health/National Cancer Institute [P50 CA9368305]
- National Institutes of Health/National Institute of Allergy and Infectious Diseases [R01 A1025082]
- Damon Runyon Clinical Investigator Award
- Leukemia & Lymphoma Society
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01AR056720]
- National Institutes of Health [R01 AI46784]
Ask authors/readers for more resources
Cutaneous T-cell lymphoma (CTCL) encompasses leukemic variants (L-CTCL) such as Se ' zary syndrome (SS) and primarily cutaneous variants such as mycosis fungoides (MF). To clarify the relationship between these clinically disparate presentations, we studied the phenotype of T cells from L-CTCL and MF. Clonal malignant T cells from the blood of L-CTCL patients universally coexpressed the lymph node homing molecules CCR7 and L-selectin as well as the differentiation marker CD27, a phenotype consistent with central memory T cells. CCR4 was also universally expressed at high levels, and there was variable expression of other skin addressins (CCR6, CCR10, and CLA). In contrast, T cells isolated from MF skin lesions lacked CCR7/L-selectin and CD27 but strongly expressed CCR4 and CLA, a phenotype suggestive of skin resident effector memory T cells. Our results suggest that SS is a malignancy of central memory T cells and MF is a malignancy of skin resident effector memory T cells. (Blood. 2010;116(5):767-771)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available