Journal
BLOOD
Volume 116, Issue 4, Pages 625-627Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-01-259028
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Funding
- Netherlands Organization for Scientific Research (NWO) [016.048.603, 917.96.350, 836.07.002]
- GlaxoSmithKline
- University of Utrecht
- Dutch Government
- Nycomed
- AstraZeneca
- Danone
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Neutrophils are essential effector cells of the innate immune response and are indispensable for host defense. Apart from their antimicrobial functions, neutrophils inform and shape subsequent immunity. This immune modulatory functionality might however be considered limited because of their generally accepted short lifespan (< 1 day). In contrast to the previously reported short lifespans acquired by ex vivo labeling or manipulation, we show that in vivo labeling in humans with the use of (H2O)-H-2 under homeostatic conditions showed an average circulatory neutrophil lifespan of 5.4 days. This lifespan is at least 10 times longer than previously reported and might lead to reappraisal of novel neutrophil functions in health and disease. (Blood. 2010; 116(4): 625-627)
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