Journal
BLOOD
Volume 116, Issue 22, Pages 4444-4455Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-03-272625
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Funding
- Inserm
- Institut de Cancerologie et d'Immuno-Genetique (ICIG)
- ARC/Inca
- Groupement des Entreprises Francaises dans la Lutte contre le Cancer (GEFLUC)
- Ministere de l'Education Nationale de la Recherche et de la Technologie (MENRT)
- Association ANRB Vaincre le Cancer
- Societe Francaise d'Hematologie (SFH)
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Edification of the human hematopoietic system during development is characterized by the production of waves of hematopoietic cells separated in time, formed in distinct embryonic sites (ie, yolk sac, truncal arteries including the aorta, and placenta). The embryonic liver is a major hematopoietic organ wherein hematopoietic stem cells (HSCs) expand, and the future, adult-type, hematopoietic cell hierarchy becomes established. We report herein the identification of a new, transient, and rare cell population in the human embryonic liver, which coexpresses VE-cadherin, an endothelial marker, CD45, a pan-hematopoietic marker, and CD34, a common endothelial and hematopoietic marker. This population displays an outstanding self-renewal, proliferation, and differentiation potential, as detected by in vitro and in vivo hematopoietic assays compared with its VE-cadherin negative counterpart. Based on VE-cadherin expression, our data demonstrate the existence of 2 phenotypically and functionally separable populations of multipotent HSCs in the human embryo, the VE-cadherin(+) one being more primitive than the VE-cadherin(-) one, and shed a new light on the hierarchical organization of the embryonic liver HSC compartment. (Blood. 2010;116(22):4444-4455)
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