Journal
BLOOD
Volume 115, Issue 16, Pages 3249-3257Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-08-237586
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Funding
- United Kingdom Biotechnology and Biological Sciences Research Council
- BBSRC
- Biotechnology and Biological Sciences Research Council [BB/F02066X/1, BBS/E/B/0000C206] Funding Source: researchfish
- Medical Research Council [G0601618] Funding Source: researchfish
- BBSRC [BB/F02066X/1] Funding Source: UKRI
- MRC [G0601618] Funding Source: UKRI
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The guanosine triphosphatases (GTPases) of the immunity-associated protein (GIMAP) family of putative GTPases has been implicated in the regulation of T-lymphocyte development and survival. A mouse conditional knockout allele was generated for the immune GTPase gene GIMAP1. Homozygous loss of this allele under the influence of the lymphoid-expressed hCD2-iCre recombinase transgene led to severe (> 85%) deficiency of mature T lymphocytes and, unexpectedly, of mature B lymphocytes. By contrast there was little effect of GIMAP1 deletion on immature lymphocytes in either B or T lineages, although in vitro studies showed a shortening of the survival time of both immature and mature CD4(+) single-positive thymocytes. These findings show a vital requirement for GIMAP1 in mature lymphocyte development/survival and draw attention to the nonredundant roles of members of the GIMAP GTPase family in these processes. (Blood. 2010; 115(16): 3249-3257)
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