Journal
CLINICAL OPHTHALMOLOGY
Volume 10, Issue -, Pages 251-256Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OPTH.S100429
Keywords
cataract surgery; endophthalmitis; intracameral antibiotic; intravitreal injection; prophylaxis
Categories
Funding
- National Institutes of Health Center Core Grant [P30EY014801]
- Research to Prevent Blindness, New York, NY
- NATIONAL EYE INSTITUTE [P30EY014801] Funding Source: NIH RePORTER
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Endophthalmitis remains a rare but important cause of visual loss. Prophylaxis strategies are important to reduce rates of endophthalmitis after cataract surgery, intravitreal injection, and other procedures. There is substantial variability between the US and the rest of the world. During cataract surgery, intracameral antibiotics are commonly used in many nations, especially in Europe, but are less commonly used in the US. A randomized clinical trial from the European Society of Cataract and Refractive Surgeons reported an approximately fivefold reduction in endophthalmitis rates associated with intracameral cefuroxime but these results are controversial. There are no randomized clinical trials regarding endophthalmitis associated with intravitreal injection. Topical antibiotics are commonly used in many nations, but are less commonly used in the US. At this time, there is no global consensus and it appears unlikely that additional major clinical trials will conclusively define the optimal endophthalmitis prophylaxis techniques.
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