Journal
BLOOD
Volume 116, Issue 2, Pages 183-192Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-10-247130
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Funding
- Swedish Medical Research Council
- Swedish Cancer Society
- Swedish Pediatric Cancer Society
- Hemato-Linne grant
- Iranian Ministry of Health
- Swedish Foundation for Strategic Research
- MRC [G0801073] Funding Source: UKRI
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Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. (Blood. 2010; 116(2): 183-192)
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