Journal
BLOOD
Volume 114, Issue 11, Pages 2263-2272Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-01-200410
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Funding
- National Blood Foundation
- Macropa Foundation
- Dutch Cancer Society [UL 2005-3657]
- Netherlands Organization for Scientific Research
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Bidirectional cell transfer during pregnancy frequently leads to postpartum persistence of allogeneic cells and alloimmune responses in both the mother and in her offspring. The life-long consequences of naturally acquired alloimmune reactivity are probably of importance for the outcome of allogeneic stem cell transplantation. We investigated the presence of CD8(pos) minor histocompatibility (H) antigen-specific cytotoxic T lymphocytes (T-CTL) and CD8(pos) minor H antigen-specific T regulator cells (T-REG) in peripheral blood cells obtained from 17 minor H antigen-disparate mother-offspring pairs. Absence of minor H antigen-specific T-REG, as marked by the feasibility to expand T-CTL from isolated tetramer(pos) populations, was observed in 6 mothers and 1 son. The presence of minor H alloantigen-specific T-REG was observed in 4 mothers and 5 sons. These T-REG were detected within isolated tetramer(dim) staining fractions and functioned in a CTLA-4-dependent fashion. Our study indicates that both T-CTL and T-REG mediated alloimmunity against minor H antigens may be present in healthy female and male hematopoietic stem cell donors, potentially influencing graft-versus-host reactivity in different ways. (Blood. 2009; 114: 2263-2272)
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