Journal
BLOOD
Volume 115, Issue 9, Pages 1727-1734Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-06-225417
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- Bayer/Talecris/CBS/HQ Partnership Fund
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Several clinical studies done with intravenous immunoglobulin (IVIg)-treated autoimmune patients as well as several in vitro studies have revealed that IVIg can reduce polyclonal T-cell activation and modify their cytokine secretion pattern. However, their effect on (auto) antigen-specific T-cell responses has never been addressed directly. In the present work, we used an in vivo model of induction of antigen-specific T-cell responses and an in vitro antigen presentation system to study the effects of IVIg on T-cell responses. The results obtained showed that IVIg inhibited both the in vivo and in vitro antigen-specific T-cell responses but that this effect was the indirect consequence of a reduction in the antigen presentation ability of antigen-presenting cells. The inhibitory effect of IVIg was Fc gamma RIIb-independent, suggesting that IVIg must interfere with activating Fc gamma Rs expressed on antigen-presenting cells to reduce their ability to present antigens. Such inhibition of T-cell responses by reducing antigen presentation may therefore contribute to the well-known antiinflammatory effects of IVIg in autoimmune diseases. (Blood. 2010;115:1727-1734)
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