Journal
BLOOD
Volume 113, Issue 17, Pages 3961-3968Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-08-176321
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Funding
- Swiss National Science Foundation [PPOOA-68805, PP00A-116896, PPOOA3-116894]
- Boehringer Ingelheim Fonds
- Mobiliar and Julia Bangerter-Rhyner Foundation
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Interleukin-7 (IL-7) is crucial for the development of T and B lymphocytes from common lymphoid progenitors (CLPs) and for the maintenance of mature T lymphocytes. Its in vivo role for dendritic cells (DCs) has been poorly defined. Here, we investigated whether IL-7 is important for the development or maintenance of different DC types. Bone marrow-derived DCs expressed the IL-7 receptor (IL-7R) and survived significantly longer in the presence of IL-7. Migratory DCs (migDCs) isolated from lymph nodes also expressed IL-7R. Surprisingly, IL-7R was not required for their maintenance but indirectly for their development. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) resident in lymph nodes and spleen were IL-7R(-). Using mixed bone marrow chimeras, we observed an intrinsic requirement for IL-7R signals in their development. As the number of CLPs but not myeloid progenitors was reduced in the absence of IL-7 signals, we propose that a large fraction of cDCs and pDCs derives from CLPs and shares not only the lymphoid origin but also the IL-7 requirement with lymphocyte precursors. (Blood. 2009;113:3961-3968)
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