Journal
BLOOD
Volume 113, Issue 9, Pages 2038-2046Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-06-162495
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Funding
- American Cancer Research Society Scholar Grant (Oakland, CA)
- USPHS National Research Service Award [GM07104]
- Hamburger Estate fund and Bergman fund of the Jonsson Comprehensive Cancer Center
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The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1-like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream of etsrp, scl, and spi-1/pu.1 in myeloid differentiation. Spi-1l is coexpressed in a subset of spi-1/pu.1 cells and its function is necessary and sufficient for macrophage and granulocyte differentiation. These results establish a critical role for spi-1l in zebrafish myeloid cell differentiation. (Blood. 2009; 113: 2038-2046)
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