Journal
NEPHRON
Volume 133, Issue 1, Pages 53-61Publisher
KARGER
DOI: 10.1159/000445171
Keywords
Kidney disease; Mouse models; Fibrosis; Mouse
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Funding
- Physician Scientist Program at the University of Heidelberg, Faculty of Medicine
- EU 7th Framework Programme (EURenOmics) [2012-305608]
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Animal models are essential tools to understand the mechanisms underlying the development and progression of renal disease and to study potential therapeutic approaches. Recently, interventional models suitable to induce acute and chronic kidney disease in the mouse have become a focus of interest due to the wide availability of genetically engineered mouse lines. These models differ by their damaging mechanism (cell toxicity, immune mechanisms, surgical renal mass reduction, ischemia, hypertension, ureter obstruction etc.), functional and histomorphological phenotype and disease evolution. The susceptibility to a damaging mechanism often depends on strain and gender. The C57BL/6 strain, the most commonly used genetic background of transgenic mice, appears to be relatively resistant against developing glomerulosclerosis, proteinuria and hypertension. This review serves to provide a comprehensive overview of interventional mouse models of acute and chronic kidney disease. (C) 2016 S. Karger AG, Basel
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