Journal
BLOOD
Volume 112, Issue 13, Pages 4793-4807Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-08-077941
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Funding
- Canadian Institutes of Health Research (CIHR)
- Ontario Institute for Cancer Research
- Province of Ontario, Genome Canada
- Ontario Genomics Institute, the Leukemia & Lymphoma Society
- National Cancer Institute of Canada
- Canadian Cancer Society
- Terry Fox Foundation
- CSL
- Arius
- Canada Research Chair
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Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the individual cells that make up the tumor exhibit considerable variation in many properties, including morphology, proliferation kinetics, and the ability to initiate tumor growth in transplant assays. Understanding the molecular and cellular basis of this heterogeneity has important implications in the design of therapeutic strategies. The mechanistic basis of tumor heterogeneity has been uncertain; however, there is now strong evidence that cancer is a cellular hierarchy with cancer stem cells at the apex. This review provides a historical overview of the influence of hematology on the development of stem cell concepts and their linkage to cancer. (Blood. 2008; 112:4793-4807)
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