Journal
BLOOD
Volume 113, Issue 3, Pages 563-566Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-06-162750
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Funding
- National Institutes of Health
- National Heart, Lung and Blood Institute (NHLBI) [HL63736, HL55337]
- American Heart Association predoctoral fellowship
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Emerging evidence suggests that all hematopoietic and endothelial cells originate from Flk-1(+) mesoderm in the mouse. However, this concept has not been completely proven, especially for the origin of blood cells. Using either Flk1(+)/Cre; Rosa26R-EYFP or Flk1(+/Cre); Rosa26R-LacZ mice, we permanently marked Flk-1(+) cells and their progenies to determine the relationship between hematopoietic tissues and cells that express Flk-1. In embryos, all blood cells within the yolk sac and aorta were of Flk-1(+) origin. In addition, nearly all CD45(+) cells in bone marrow and circulating blood in adults were of Flk-1(+) origin. These results provide clear evidence that all blood cells, primitive and definitive, in mice are derived from Flk-1(+) mesodermal cells. (Blood. 2009; 113: 563-566)
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