Journal
BLOOD
Volume 112, Issue 4, Pages 1515-1521Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2007-11-125542
Keywords
-
Categories
Funding
- NCI NIH HHS [T32 CA88784-04, T32 CA009676, P01 CA039542, P01 CA39542, T32 CA088784] Funding Source: Medline
Ask authors/readers for more resources
Extracorporeal photopheresis (ECP), a technique that exposes isolated white blood cells to photoactivatable 8-methoxypsoralen and ultraviolet A radiation, is used clinically to treat cutaneous T-cell lymphoma and immune-mediated diseases such as graft-versus-host disease (GVHD). ECP is thought to control these diseases in part through direct induction of lymphocyte apoptosis, but its effects on the immune system beyond apoptosis remain poorly characterized. We have developed a novel method for incorporating ECP treatment into well-established and clinically relevant murine models of GVHD to examine its effects during an ongoing immune response. We demonstrate that the transfer of cells treated with ECP reverses established GVHD by increasing donor regulatory T cells and indirectly reducing the number of donor effector lymphocytes that themselves had never been exposed to psoralen and ultraviolet A radiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available