Journal
BLOOD
Volume 113, Issue 7, Pages 1395-1396Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-11-185801
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MLL5 is an MLL family protein and a candidate tumor suppressor located within the human chromosome band 7q22 that is frequently deleted in myeloid malignancies. In this issue of Blood, 3 independent studies report the first genetic analysis of MLL5 deficiency in mice. All 3 strains of MLL5 knockout mice exhibited defects in hematopoiesis, highlighting the critical role of MLL5 in hematopoietic stem cell functions.
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