4.6 Article

A strategy for rapid and facile fabrication of controlled, layered blood vessel-like structures

Journal

RSC ADVANCES
Volume 6, Issue 60, Pages 55054-55063

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra12768a

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Funding

  1. National Natural Science Foundation of China [31170905, 51373043, 81361140345, 21535001]
  2. Chinese Academy of Science [XDA09030305]
  3. CAS/SAFEA International Partnership Program for Creative Research Teams

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We develop a rapid and facile method to fabricate tubular scaffolds by a single-step rolling operation. With the aid of fibrin medical glue and a smooth expanded polytetrafluoroethylene (ePTFE) mandrel, we can wrap a piece of flat thin film into a three-dimensional (3D), multi-layered tubular structure with well-controlled diameter, wall thickness, and mechanical strength within 10 min. By patterning different cells in a pre-designed area on the film, after rolling, we can obtain blood vessel-mimicking tissues with well-arranged, multilayered 3D architectures within 70 min. Our strategy provides an excellent platform to rapidly fabricate tubular scaffolds essentially with no equipment and straightforward manipulations.

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