Journal
BLOOD
Volume 113, Issue 4, Pages 807-815Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-08-173682
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- Leukemia & Lymphoma Society
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Ongoing thymopoiesis requires continual seeding from progenitors that reside within the bone marrow ( BM), but the identity of the most proximate prethymocytes has remained controversial. Here we take a comprehensive approach to prospectively identify the major source of thymocyte progenitors that reside within the BM and blood, and find that all thymocyte progenitor activity resides within a rare Flk2(+)CD27(+) population. The BM Flk2(+)CD27(+) subset is predominantly composed of common lymphoid progenitors (CLPs) and multipotent progenitors. Of these 2 populations, only CLPs reconstitute thymopoiesis rapidly after intravenous injection. In contrast, multipotent progenitor-derived cells reconstitute the thymus with delayed kinetics only after they have reseeded the BM, self-renewed, and generated CLPs. These results identify CLPs as the major source of thymocyte progenitors within the BM. (Blood. 2009;113:807-815)
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