Journal
GUT MICROBES
Volume 7, Issue 4, Pages 323-328Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2016.1151608
Keywords
dysbiosis; Inflammatory bowel disease; Steroids; Step-up fecal microbiota transplantation; Ulcerative colitis
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Funding
- National Gastroenterology Research Project [2015BAI13B07]
- Clinical Science and Technology Foundation of Jiangsu Province [BL2014097]
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Gut dysbiosis is a characteristic of inflammatory bowel disease (IBD) and is believed to play a role in the pathogenesis of IBD. Fecal microbiota transplantation (FMT) is an effective strategy to restore intestinal microbial diversity and has been reported to have a potential therapeutic value in IBD. Our recent study reported a holistic integrative therapy called step-up FMT strategy, which was beneficial in treating steroid-dependent IBD patients. This strategy consists of scheduled FMTs combined with steroids, anti-TNF-alpha antibody treatment or enteral nutrition. Herein, we will elaborate the strategy thoroughly, introducing the concept, potential indication, methodology, and safety of step-up FMT strategy in detail.
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