Journal
EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT
Volume 1, Issue 1, Pages 93-108Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/23808993.2016.1140004
Keywords
Cell therapies; cryo-banking; cryopreservation; customization; personalized medicine; off-the-shelf; tissue engineering; translational platforms
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Funding
- Portuguese Foundation for Science and Technology for the post-doctoral grant [SFRH/BPD/111729/2015]
- Recognize [UTAP-ICDT/CTM-BIO/0023/2014]
- 2 (NSRF), through ERDF [project RL3 -TECT -NORTE-07-0124-FEDER-000020]
- Fundação para a Ciência e a Tecnologia [UTAP-ICDT/CTM-BIO/0023/2014] Funding Source: FCT
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Personalized tissue engineering and regenerative medicine (TERM) therapies propose patient-oriented effective solutions, considering individual needs. Cell-based therapies, for example, may benefit from cell sources that enable easier autologous set-ups or from recent developments on IPS cells technologies towards effective personalized therapeutics. Furthermore, the customization of scaffold materials to perfectly fit a patient's tissue defect through rapid prototyping technologies, also known as 3D printing, is now a reality. Nevertheless, the timing to expand cells or to obtain functional in vitro tissue substitutes prior to implantation prevents advancements towards routine use upon patient's needs. Thus, personalized therapies also anticipate the importance of creating off-the-shelf solutions to enable immediately available tissue engineered products. This paper reviews the main recent developments and future challenges to enable personalized TERM approaches and to bring these technologies closer to clinical applications.
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