Journal
NEUROHOSPITALIST
Volume 6, Issue 1, Pages 24-28Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1941874415591702
Keywords
brain neoplasms; nervous system neoplasms; meningeal neoplasms; imaging; techniques
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The diagnosis of leptomeningeal metastasis (LM) has increased in frequency, as new therapies have lengthened the survival of patients with cancer. Early diagnosis and intervention help improve quality of life and prevent further neurological deterioration in LM. The detection of LM is often established by magnetic resonance imaging examinations, cerebrospinal fluid analysis, or both. We present a series of cases where LM was identified on fluid-attenuated inversion recovery or T2-weighted image but was nonenhancing on the traditionally more sensitive postcontrast T1-weighted sequences. Nonenhancing LM is unusual and not yet fully understood but should be considered in the appropriate clinical context and may become more common with increased utilization of antiangiogenic therapies.
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