Journal
BJU INTERNATIONAL
Volume 105, Issue 1, Pages 8-13Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1464-410X.2009.08921.x
Keywords
prostate cancer; hypoxia; radiotherapy; hypoxia-inducible factor-1; vascular endothelial growth factor
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Funding
- MRC [G0501019] Funding Source: UKRI
- Medical Research Council [G0501019] Funding Source: Medline
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Research into the hypoxic tumour microenvironment is accelerating and the reversal of hypoxia is increasingly being suggested as a mechanism for improving cancer treatment. Recent studies have suggested that hypoxia is also a feature in prostate cancer and is associated with a poor prognosis. Hypoxia has been shown to cause radio-resistance and hence hamper one of the major treatments for prostate cancer. However, unlike other solid tumours, such as cervical and head-and-neck cancer, there are inconsistencies and unanswered questions about the relevance of hypoxia in prostate cancer. This review outlines the role of low-oxygen conditions in prostate cancer and the areas where further studies are required.
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