Journal
ENVIRONMENTAL EPIGENETICS
Volume 2, Issue 1, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eep/dvv015
Keywords
epigenetic inheritance; artificial insemination; germline-dependence; mice; transgenerational; sperm
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Funding
- University of Zurich, ETH Zurich
- Swiss National Science Foundation
- Roche
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We developed a simple, noninvasive artificial insemination technique to study epigenetic germline inheritance in mice. This technique avoids interfering factors introduced by superovulation, surgery, in vitro culture or mating that can confound the transmission of acquired epigenetic information through the germline. Using a stress model, we demonstrate that our method is suited to test the causal involvement of the male germline in transmitting acquired information from father to offspring.
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