Journal
BJU INTERNATIONAL
Volume 106, Issue 11, Pages 1788-1793Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1464-410X.2010.09312.x
Keywords
diabetes mellitus; erection; nNOS; penile tissue; vitamin E
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Funding
- Ana Paula de Santi Rampazzo
- Maria Eurides do Carmo Cancino
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OBJECTIVE To investigate the effects of 0.1% and 2% vitamin E (alpha-tocopherol) supplementation on the expression of nitric oxide (NO) in penile tissue of rats with experimentally induced diabetes mellitus (DM). MATERIALS AND METHODS In all, 30 male rats were divided into six groups: normoglycaemic (NG), NG treated with 0.1% vitamin E (NGE1), NG treated with 2% vitamin E (NGE2), DM, DM treated with 0.1% vitamin E (DME1), and DM treated with 2% vitamin E (DME2). After 120 days the rats were killed, and penile tissue was collected and processed for neuronal NO synthase (nNOS) immunohistochemistry to determine areas of nNOS-immunoreactive varicosities. RESULTS nNOS-immunoreactive varicosities in DME2 rats were similar to those of controls (NG) and controls supplemented with vitamin E (NGE1 and NGE2). Varicosity sizes in the NGE1 group were similar to the DM rats with no vitamin E supplementation. CONCLUSION Supplementation with 2% vitamin E had a positive effect on areas of nNOS-immunoreactive varicosities of penile tissue in DM rats.
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