Journal
TISSUE BARRIERS
Volume 4, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21688370.2015.1134415
Keywords
exosomes; exosome-like nanoparticles; natural lipid nanoparticles; plant edible nanoparticles; therapeutic
Categories
Funding
- Department of Veterans Affairs [BX002526]
- National Institutes of Health of Diabetes and Digestive and Kidney [RO1-DK-071594]
- Crohn's & Colitics Foudation of America
- Department of Veterans Affairs
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK071594] Funding Source: NIH RePORTER
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In plant cells, nanoparticles containing miRNA, bioactive lipids and proteins serve as extracellular messengers to mediate cell-cell communication in a manner similar to the exosomes secreted by mammalian cells. Notably, such nanoparticles are edible. Moreover, given the proper origin and cargo, plant derived edible nanoparticles could function in interspecies communication and may serve as natural therapeutics against a variety of diseases. In addition, nanoparticles made of plant-derived lipids may be used to efficiently deliver specific drugs. Plant derived edible nanoparticles could be more easily scaled up for mass production, compared to synthetic nanoparticles. In this review, we discuss recent significant developments pertaining to plant derived edible nanoparticles and provide insight into the use of plants as a bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles.
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