Journal
GENES AND ENVIRONMENT
Volume 38, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s41021-016-0033-0
Keywords
Non-steroidal anti-inflammatory drugs; Colorectal cancer; Risk factors; Chemoprevention
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Funding
- Japan Society for the Promotion of Science (JSPS KAKENHI) [25290049]
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [16K07303] Funding Source: KAKEN
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Evidence from epidemiological and experimental studies has shown that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colorectal cancer (CRC). The function of NSAIDs and the molecular targets for chemopreventive effects on CRC have been extensively studied and their data were reported. However, the relation between NSAIDs and the risk factors of CRC have not been fully elucidated yet. Thus, relations between NSAIDs and the risk factors of CRC, such as overweight and obesity, alcohol, aging, hypertriglyceridemia and smoking, are summarized with our data and with recent reported data in this review.
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