Journal
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 120, Issue 6, Pages 758-764Publisher
WILEY-BLACKWELL
DOI: 10.1111/1471-0528.12173
Keywords
Image-guided surgery; indocyanine green; near-infrared fluorescence imaging; sentinel lymph node mapping; vulvar cancer
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Funding
- National Institutes of Health [R01-CA-115296, R21-CA-130297]
- Dutch Cancer Society [UL2010-4732]
- CTMM, the Center for Translational Molecular Medicine, project MUSIS [03O-202]
- Netherlands Organisation for Health Research and Development
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This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received 99mTc-nanocolloid and patent blue for SLN detection. Subsequently, women randomly received ICG:HSA or ICG alone. In 24 women, 35 SLNs were intraoperatively detected. All SLNs detected were radioactive and NIR fluorescent and 27 (77%) were blue. No significant difference was found between ICG:HSA and ICG alone. This trial confirms the feasibility of NIR fluorescence imaging for SLN mapping in vulvar cancer.
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