Journal
BIOMATERIALS
Volume 114, Issue -, Pages 97-105Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.11.010
Keywords
Photothermal therapy; Bone targeting; Bone tumor; Osteoclastic bone resorption
Funding
- National Key Research and Development Program of China [2016YFC0902100]
- National Natural Science Foundation of China [81671822]
- Basic Research Program of Science and Technology Commission of Shanghai Municipality [14JC1491100]
- Fok Ying Tong Education Foundation [151036]
- Shanghai Pujiang Program [14PJD016]
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The treatment of bone tumors is a challenging problem due to the inefficient delivery of therapeutics to bone and the bone microenvironment-associated tumor resistance to chemo- and radiotherapy. Here, we developed a bone-targeted nanoparticle, aspartate octapeptide-modified dendritic platinum-copper alloy nanoparticle (Asp-DPCN), for photothermal therapy (PTT) of bone tumors. Asp-DPCN showed much higher affinity toward hydroxyapatite and bone fragments than the non-targeted DPCN in vitro. Furthermore, Asp-DPCN accumulated more efficiently around bone tumors in vivo, and resulted in a higher temperature in bone tumors during PIT. Finally, Asp-DPCN-mediated nu not only efficiently depressed the tumor growth but also significantly reduced the osteoclastic bone destruction. Our study developed a promising therapeutic approach for the treatment of bone tumors. (C) 2016 Elsevier Ltd. All rights reserved.
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