H2O2-responsive theranostic nanomedicine

The fast progress of stimuli-responsive theranostic nanomedicine can achieve the specific and high-performance diagnosis and therapy of various diseases. Especially, H2O2-responsive theranostic nanomedicine is recently emerging as a new stimuli-responsive modality showing the great potential for the theranostic of diseases with overexpressed H2O2 because H2O2 is associated with several kinds of human diseases as the most stable and abundant reactive oxygen species. This review summarizes and discusses the very-recent developments of H2O2-responsive theranostic nanoplatforms for versatile biomedical applications, including diagnostic imaging, attenuating tumor hypoxia, enhancing the therapeutic efficiency of photodynamic therapy/radiation therapy/chemotherapy and theranostic of inflammation/diabetic. The facing challenges and future developments of H2O2-responisve theranostics are also briefly discussed to further promote the clinical translation of this new responsive theranostic modality. It is highly believed that H2O2-responsive theranostic nanomedicine will be extensively developed a new specific and efficient theranostic modality to benefit the personalized biomedicine in the near future. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.