Journal
CELL CYCLE
Volume 16, Issue 19, Pages 1835-1847Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2017.1361569
Keywords
hematopoiesis; hematopoietic stem cells; hemogenic endothelium
Categories
Funding
- NSF
- CIRM pre-doctoral fellowships
- Burroughs Wellcome Fund CAMS award [1008408.01]
- NIH Innovator Award program [1DP2HL117743-01]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [DP2HL117743] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008568] Funding Source: NIH RePORTER
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The emergence of haematopoietic stem and progenitor cells (HSPCs) from hemogenic endothelium results in the formation of sizeable HSPC clusters attached to the vascular wall. We evaluate the cell cycle and proliferation of HSPCs involved in cluster formation, as well as the molecular signatures from their initial appearance to the point when cluster cells are capable of adult engraftment (definitive HSCs). We uncover a non-clonal origin of HSPC clusters with differing cell cycle, migration, and cell signaling attributes. In addition, we find that the complement cascade is highly enriched in mature HSPC clusters, possibly delineating a new role for this pathway in engraftment.
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