Journal
AQUATIC TOXICOLOGY
Volume 191, Issue -, Pages 236-244Publisher
ELSEVIER
DOI: 10.1016/j.aquatox.2017.08.015
Keywords
Electrocardiogram; Zebra fish; Cadmium chloride; Water quality; Correlation analysis
Categories
Funding
- Natural Science Foundation of China [21107135]
- Oversea High-level Talent Project of Ji'nan [2013041]
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The electrocardiogram (ECG) of zebra fish (Dania rerio) expresses cardiac features that are similar to humans. Here we use sharp microelectrode measurements to obtain ECG characteristics in adult zebra fish and analyze the effects of cadmium chloride (CdCl2) on the heart. We observe the overall changes of ECG parameters in different treatments (0.1 TU, 0.5 TU and 1.0 TU CdCl2), including P wave, Q wave, R wave, S wave, T wave, PR interval (atrial contraction), QRS complex (ventricular depolarization), ST segment, and QT interval (ventricular repolarization). The trends of the ECG parameters showed some responses to the concentration and exposure time of CdCl2\, but it was difficult to obtain more information about the useful indicators in water quality assessment depending on tendency analysis alone. A self-organizing map (SOM) showed that P values, R values, and T values were similar; R wave and T wave amplitude were similar; and most important, QRS value was similar to the CdCl2 stress according to the classified data patterns including CdCl2 stress (E) and ECG components based on the Ward linkage. It suggested that the duration of QRS complex was related to environmental stress E directly. The specification and evaluation of ECG parameters in Cd2+ pollution suggested that there is a markedly significant correlation between QRS complex and CdCl2 stress with the highest r (0.729) and the smallestp (0.002) among all ECG characteristics. In this case, it is concluded that QRS complex can be used as an indicator in the CdCl2 stress assessment due to the lowest AIC data abased on the linear regression model between the CdCl2 stress and ECG parameters.
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