Journal
CHINESE JOURNAL OF CHEMICAL ENGINEERING
Volume 25, Issue 10, Pages 1461-1466Publisher
CHEMICAL INDUSTRY PRESS
DOI: 10.1016/j.cjche.2017.05.002
Keywords
Solubility; Meropenem trihydrate; Thermodynamics
Categories
Funding
- Tianjin Municipal Natural Science Foundation [16JCYBJC19500]
- China Ministry of Science and Major National Scientific Instrument Development Project [2016YFF0102503]
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The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from T=( 278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data, experimental solubility data in two kinds of binary solventmixtureswere correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results. (C) 2017 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.
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