Journal
DRUG DISCOVERY TODAY
Volume 22, Issue 9, Pages 1421-1429Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2017.04.008
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Funding
- National Cancer Institute (NCI) [R21CA190196]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [R21AR06630, 2R01AR054458]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [R01 HD081123-01A1]
- Agency for Science, Technology and Research (A*STAR, Singapore)
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD081123] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R21CA190196] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR054458, R21AR066302] Funding Source: NIH RePORTER
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Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO nanoparticles for cancer theranostics and discusses current challenges and future perspectives.
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