Journal
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
Volume 125, Issue 7, Pages 579-583Publisher
CERAMIC SOC JAPAN-NIPPON SERAMIKKUSU KYOKAI
DOI: 10.2109/jcersj2.17016
Keywords
Composites; Biomedical applications; Hydroxyapatite/collagen composite; Injectable bone paste; Calcium citrate; Sodium alginate
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Funding
- SASTRA University, India
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Influences of combined supplementation of calcium citrate (Ca-Cit) and calcium carbonate (CaCO3) on the hydroxyapatite/collagen (HAp/Col)-sodium alginate (Na-Alg) paste (HAp/Col paste) were investigated. Supplementation amounts of Ca-Cit and CaCO3 were denoted as Nx, where N is a multiplication number to Ca2+ ion amounts for the equivalent reaction with Na-Alg obtained previously. Combined supplementation of 10x Ca-Cit and 2x CaCO3 improved the anti-washout property at a washout ratio of 2.42 +/- 0.72% and pH maintenance at 7.34 +/- 0.08, these values were better than the best HAp/Col paste using Ca-Cit (5.91 +/- 2.73% washout ratio and 6.72 +/- 0.06 of pH). This is due to coordinate effects of initial washout inhibition by weak but rapid formation of long-range network by citric acid followed by long term anti-washout inhibition by strong but slow network formation by Ca2+ ions. The paste also showed good cytocompatibilty that MG63 cells proliferated with the culture time without any significant difference with the HAp/Col dense bodies. The HAp/Col paste is expected to be utilized in minimally invasive surgery of bone defect. (C)2017 The Ceramic Society of Japan. All rights reserved.
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