Journal
CANCER BIOMARKERS
Volume 20, Issue 4, Pages 357-367Publisher
IOS PRESS
DOI: 10.3233/CBM-170258
Keywords
Pancreatic cancer; pancreatic intraepithelial neoplasia; early detection; exosomes; immune tolerance
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Funding
- Natural Science Foundation of Fujian Province [2017J01547]
- Science and Technology Project of the Education Department of Fujian Province [JA15445]
- National Natural Science Foundation of China [81571613, 81572442, 21405016]
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Pancreatic cancers with poor prognosis are highly malignant, readily metastatic and of immune tolerance, mainly due to delayed detection. The metastatic progression and immune tolerance of pancreatic cancer is greatly attributed to the intercellular communication. However, exosomes are deemed to be the most important tool of intercellular communicators. Thus, we present a review of pancreatic cancer and exosomes in this article. We intensively summarize the progress of early pancreatic cancer and the relationship of the proliferation, progression and metastasis of pancreatic cancer and pancreatic cancer-derived exosomes, and propose new ideas of the study of pancreatic cancer.
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