Journal
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
Volume 93, Issue 1, Pages 51-55Publisher
WILEY-BLACKWELL
DOI: 10.1002/bdrc.20199
Keywords
epigenetics; development; environment; transgenerational; systems biology; differentiation; disease etiology
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Funding
- NIEHS NIH HHS [R01 ES012974] Funding Source: Medline
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The molecular mechanisms involved in developmental biology and cellular differentiation have traditionally been considered to be primarily genetic. Environmental factors that influence early life critical windows of development generally do not have the capacity to modify genome sequence, nor promote permanent genetic modifications. Epigenetics provides a molecular mechanism for environment to influence development, program cellular differentiation, and alter the genetic regulation of development. The current review discusses how epigenetics can cooperate with genetics to regulate development and allow for greater plasticity in response to environmental influences. This impacts area such as cellular differentiation, tissue development, environmental induced disease etiology, epigenetic transgenerational inheritance, and the general systems biology of organisms and evolution. Birth Defects Research (Part C) 93:51-55, 2011. (C) 2011 Wiley-Liss, Inc.
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