Journal
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
Volume 87, Issue 3, Pages 249-262Publisher
WILEY
DOI: 10.1002/bdrc.20157
Keywords
BMP; FGF; Wnt; neural stem cells; transcriptional network; neural fate stabilization
Categories
Funding
- NIH [NS23158, NS0489180]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0817902] Funding Source: National Science Foundation
Ask authors/readers for more resources
The neural ectoderm of vertebrates forms when the bone morphogenetic protein (BMP) signaling pathway is suppressed. Herein, we review the molecules that directly antagonize extracellular BMP and the signaling pathways that further contribute to reduce BMP activity in the neural ectoderm. Downstream of neural induction, a large number of neural fate stabilizing (NFS) transcription factors are expressed in the presumptive neural ectoderm, developing neural tube and ultimately in neural stem cells. Herein, we review what is known about their activities during normal development to maintain a neural fate and regulate neural differentiation. Further elucidation of how the NFS genes interact to regulate neural specification and differentiation should ultimately prove useful for regulating the expansion and differentiation of neural stem and progenitor cells. Birth Defects Research (Part C) 87:249-262, 2009. (C) 2009 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available