Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 49, Issue 10, Pages 935-944Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmx092
Keywords
oc-stamp; inflammation; macrophage polarization; STAT6
Categories
Funding
- National Natural Science Foundation of China [81600625, 81670735, 81400802]
- Doctoral Innovation Fund of Shanghai Jiao Tong University School of Medicine [BXJ201638]
- Shanghai Baoshan Programs for Science and Technology Development [14-E-3]
- Shanghai Pujiang Program [15PJ1405100]
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Macrophages are the key cells in metabolic syndrome and are also a risk factor for metabolic disease. Macrophages have different functions and transcriptional profiles, but all are required for maintaining homeostasis. It is well known that macrophages play a key role in inflammation and early atherogenesis, and are present in two phenotypes: pro-inflammatory (M1) and anti-inflammatory (M2). Osteoclast stimulatory transmembrane protein (oc-stamp) is a multiple-pass transmembrane protein; however, its function remains unclear. In this study, we explored the role of oc-stamp in macrophages physiology. The results showed that oc-stamp was notably decreased under LPS and IFN-gamma stimulation, while it was increased with IL-4 treatment. Furthermore, oc-stamp induced a phenotypic switch in macrophage polarization, suppressing the M1 pro-inflammatory state in the overexpression group, and promoting the M1 pro-inflammatory state in the knockdown group. Further study revealed that oc-stamp regulated macrophage polarization possibly via STAT6. Taken together, our results are the first to demonstrate that oc-stamp may play an important role in macrophage polarization and inhibit the M1 pro-inflammatory state.
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