Journal
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
Volume 67, Issue 1, Pages 101-113Publisher
IOS PRESS
DOI: 10.3233/CH-170273
Keywords
Endothelial dysfunction; microparticles; biomarkers; sST2; H-FABP; suPAR; GDF-15; endothelin; hypoxia; moderate altitude
Categories
Funding
- Actelion Deutschland
- Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg
- Clinic of Internal Medicine I, Department of Cardiology, Friedrich Schiller University Jena
Ask authors/readers for more resources
BACKGROUND: Endothelial dysfunction is accompanied by the release of microparticles (MP). OBJECTIVE: We sought to investigate the effect of moderate hypoxia on circulatory levels of microparticles, biomarkers of cardiovascular function and inflammation and on echocardiographic parameters in healthy volunteers staying at an altitude of 2978 m. METHODS: Eighteen healthy volunteers were subjected to moderate hypoxia by staying at 2978m above sea level for three days. Blood samples were evaluated for MP using flow cytometry. ELISA analysis was performed for sST2, H-FABP, suPAR and GDF-15. Moreover, the effect of dual endothelin-receptor blockade was investigated. RESULTS: Oxygen saturation decreased to 93%. A significant decrease of endothelial and platelet MP levels was found. These results were corroborated by a similar response in sST2 and suPARplasma concentration. Endothelin-receptor blockade by macitentan only had a marginal influence on MP, sST2, H-FABP, suPAR and GDF-15 levels, though it led to a significant amelioration of echocardiographic parameters of right heart function. CONCLUSIONS: These experimental results show that moderate hypoxia due to altitude exposition led to a reduction in parameters of endothelial dysfunction as shown by a decrease in endothelial and platelet MP, sST2 and suPAR levels. A slight increase in pulmonary pressure at moderate altitude was decreased by dual endothelin receptor blockade.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available