Journal
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
Volume 97, Issue 3, Pages 161-165Publisher
WILEY
DOI: 10.1002/bdra.23123
Keywords
overweight; obesity; casecontrol study; neural tube defect; risk factor
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Funding
- Mechanism Study of Folic Acid Metabolism and Relation between Obesity and Overweight and Neural Tube Defects
- National Natural Science Foundation, China [30901235]
- project of Effectiveness Evaluation of Hospital-Based Comprehensive Birth Defects Intervention Methods
- Ministry of Science and Technology, China [2006BA105A01]
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BACKGROUND Studies have suggested that being obese before pregnancy is a risk factor for neural tube defects (NTDs), while results of many studies are controversial. This study aims to explore the association between maternal overweight and obesity before pregnancy and risk of NTDs. METHODS A 1:1 matched casecontrol study was conducted. Cases were 459 women who delivered infants or conceived fetuses with NTDs in two provinces of China and controls were 459 women with live-born infants, without an apparent congenital malformation, matched with cases by region, delivery hospital, and year of childbirth. RESULTS Compared with normal body weight, maternal obesity (body mass index, BMI 28 kg/m2) before pregnancy had a significant increased risk for NTDs as a group after adjusting for age, occupation, educational level, family income, parity, and use of folic acid (odds ratio, OR = 2.45; p < 0.05). No significant increase in NTD risk was found for maternal underweight (BMI < 18.5 kg/m2) and overweight (BMI from 24 to 28 kg/m2). For three subtypes of NTDs, anencephaly, spina bifida, and encephalocele, no significant increase in risk was found with maternal underweight, overweight, or obesity (all, p > 0.05). CONCLUSION Maternal obesity before pregnancy is associated with risk of NTDs and should be considered in maternal reproductive health care. Birth Defects Research (Part A), 2013. (c) 2013 Wiley Periodicals, Inc.
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